Anti-hiv Agents: a Step towards Future
نویسندگان
چکیده
Novel targets for the management of HIV infection have become increasingly relevant in view of extensive drug resistance, side effects and high pill burden of some of the conventional anti-retroviral agents. These agents include chemokine receptor antagonists and the integrase inhibitors which were recently approved for HIV treatment, as well as numerous other agents directed to previously untested targets such as the maturation inhibitors, pharmacological CDK inhibitors, TateTAR interaction inhibitors, anti-CD4 monoclonal antibody, antisense oligonucleotides, Use of new agents with novel mechanism of action requires the development of new laboratory assays to detect viral tropism and new resistance mutations. This review discusses issues surrounding the development of these new agents as well as various traditional approaches for the treatment of AIDS.
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